Hundred Centuries Hotel Shanghai is located in the South Tibet Road in Huangpu District, intersecting Quxi Road, adjacent to the south Zhongshan Road approach bridge of Nanpu Bridge in the South and Lupu Bridge in the West. It is about 100 meters away from rail transit lines 4 and 8 and the Ninth People's hospital. It is accessible at one stop of China Art Palace, Shanghai World Expo exhibition center and Mercedes Benz Cultural Center Light Rail Line 8.
The hotel is located along Xizang Nan Road, appr. ten minutes' drive from the bustling Huaihai Road and famous Xintiandi Bar street as well.